SPORADIC APPLICATION OF ALCOHOL AS A RISK FACTOR FOR THE GENESIS OF THE DIABETES MELLITUS TYPE 2
Pereverzev V.A.
UDC: 612.393.1:616.379-008.64
Abstract: The aim of research was the analysis of interconnections between content of glucose in integrate capillaceous blood of people with different functional states (attitude of rest and mental work in fasting state, also in time of Oral Glucose Tolerance Test) and factors of using alcohol (once and monthly doses, rates of using), continuance of a period sober state. Research made with unconstrained participation of 27 male (20-29 aged) people, eventually drinking (n=19) and non-drinking (n=8) alcohol. Relation of each probationer to alcohol was identified with the help of psychometric tests. In the time of research the level of glycemia was identified in each youth. First time the level of glucose in integrate capillaceous blood was measured started from functional attitude of rest. Next 3 times the level of glycemia was measured in time of mental work after 2, 4 and 6 hours from the beginning of the work. The last 3 times - in time of Oral Glucose Tolerance Test (after 30, 60 and 120 min after using 75 grams of glucose). Then using methods of the mathematical statistic, coefficient of linear and rank correlation between indexes of using alcohol and glucose content in integrate capillaceous blood in different states and glycemia level dynamics was calculated. Abstainers in the functional attitude of rest and fasting state have optimal level of glucose in integrate capillaceous blood. It is 4.24 mmol/L. In the time of mental work of abstainers the level of glycemia constantly rises in general on 0.67; 1.16 and 1.54 mmol/L after 2, 4 and 6 hours from the beginning of the work. The glycemia level of sober young people, who drink alcohol, in fasting state is increased and exceeds the threshold of stimulating effect secretion of pancreatic hormone. In the time of mental work in fasting state after 6 hours the level of glycemia of sober persons starts to fall and become less than the threshold of stimulating effect secretion of coninsular hormones. Linear and rank correlation shows availability of significant straight (positive) correlation between contention of glucose in blood in fasting state and indexes of using ethanol (rates of using, once and monthly doses), also of significant reciprocal (negative) correlations between the level of glycemia with alcohol rates of using, once and monthly doses. In the time of the tolerance test was significantly fixed a good deal of “sugar” curve dynamics expression of sober respondents than of abstainers and its interconnections with indexes (factors) of ethanol intake (its positive) and continuance of a sober state period (negative). Dynamics intensity of “sugar” curve of sober respondents approaches to this one in case if people have diabetes mellitus. In 27.8% cases testing sobers have 10.9 and 11.0 mmol/L of glucose after taking 75 grams. This can be contemplated as early sign of disturbed tolerance to glucose and aptitude to diabetes mellitus.
Key words: глюкоза, алкоголь, этанол, сахарный диабет, glucose, alcohol, ethanol, diabetes mellitus
BIOLOGICAL PROPERTIES OF CAUSERS OF PURULENT-INFLAMMATORY PROCESSES AND THEIR REGULATION BY HERBAL REMEDIES
Frolova A.V., Okulich V.K.
UDC: 615.28:582.682:616.9-089
Abstract: The biological properties and sensitivity of the causers of purulent-inflammatory processes in otorhinolaryngology to antibiotics and to herbal medicinal remedies has been studied. The exponential expression of pathogenic and persistent potential of microorganisms depending on character and currents of wound process were defined. It was found that the lingering nature of chronic purulent-inflammatory processes due to the high adhesive and anti-lysozyme activity of the microflora. Correlation of antimicrobial resistance of Staphylococci with the expression level of anti-lysozyme activity was identified (r=0.85, p<0,01). The expediency of the use of medicinal herbal remedies as a promising antimicrobial agents in the fight against multidrug-resistant pathogens of wound infection was justified. The ability of herbal remedies be modifying activity against persistent potential of microorganisms was shown.
Key words: возбудители, биологические свойства, антибиотикорезистентность, растительные средства, pathogens, biological properties, antimicrobial resistance, herbal remedies
MITOCHONDRIAL PORE AS A PHARMACOLOGICAL TARGET
Levchenkova O.S., Novikov V.E., Pogilova E.V.
UDC: 615.015:616-001.8
Abstract: The review is devoted to the role of mitochondrial Ca -dependent pore (mPTP) in the regulation of metabolic processes in cells under physiological and pathological conditions. The mechanisms of reperfusion injury in the postischemic period involving mPTP is discussed in the paper. Possibility of pharmacological regulation of metabolic and functional processes in cells by target action on mPTP work is estimated. This approach allows to regulate key cell functions, stimulating either mechanisms of adaptation and survival in extreme conditions or apoptosis. Pharmacological modulators of the mitochondrial pore as drugs have promising value for treatment of ischemic diseases as well as tumor therapy.
Key words: митохондриальная пора (mPTP), гипоксия, ишемия, реперфузионное повреждение, регуляция апоптоза, mitochondrial pore (mPTP), hypoxia, ischemia, reperfusion injury, regulation of apoptosis
ANALYSIS OF THE APPLICATION CYCLOFERON IMMUNOMODULATOR IN THE TREATMENT OF PATIENTS WITH GASTRIC ULCER
Abramova E.S., Nikitin G.A., Fedorov G.N., Russiyanov V.V., Dukova V.S., Bazhenov S.M., Dubenskaya L.I.
UDC: 616.33-002.44+615.015
Abstract: The article presents the results of the use of cycloferon in the treatment of patients with gastric ulcer disease and its effects on the frequency of achieving Helicobacter pylori eradication at different severity and duration of disease. It was found that the addition of cycloferon to the standard treatment regimen increases the frequency of achieving eradication of Helicobacter pylori in patients with medium, severe and long-term disease course. Determination of immune status changes is desirable to support the inclusion of cycloferon immunomodulator in treatment complex of gastric ulcer.
Key words: язвенная болезнь желудка, Helicobacter pylori, иммунный статус, циклоферон, gastric ulcer, Helicobacter pylori, immune status, cycloferon
THE USE OF INSTRUMENTAL METHODS OF DIAGNOSTICS TO DETERMINE THE RELATIONSHIP BETWEEN THE STATIC AND THE HABITUAL DINAMIC OCCLUSION POSITIONS OF THE FUNCTIONAL MASTICATORY MUSCLES
Trezubov V.N., Bulycheva Y.A., Alpatyeva Y.V., Bulycheva D.S.
UDC: 616.314
Abstract: The purpose of this study was to examine the relation between the height of functional rest of masticatory muscles and habitual occlusion in patients with disorders of dental-maxillary apparatus. Spatial relation between the height of functional rest of masticatory muscles and habitual occlusion in sagittal, transversal and occlusal dimensions were determined by means of the MPI device. The following data was gathered: before treatment of muscular and articular dysfunctions in sagittal dimension it was 1.6-2.3 mm ; in transversal dimension - 1.5-2.5 mm; in occlusal dimension - 1.5-2.0 mm ; after treatment of muscular and articular dysfunctions in sagittal dimension 0.5-1.0 mm; in transversal dimension - 0.5-1.0 mm; in occlusal dimension - 0-0.5 mm.
Key words: высота функционального покоя жевательных мышц, привычная окклюзия, height of functional rest of masticatory muscles, habitual occlusion
INVESTIGATION OF THE BOND STRENGTH WITH DIFFERENT DENTIN ADHESIVE SYSTEMS
Adamov P.G., Nikolaev A.I., Birjukova M.A., Ivkina N. P., Sachenko A.P.
UDC: 616.314-21/.22
Abstract: Purpose of our probe was the experimental assessment of strength properties of adhesive communication on alteration for six adhesive systems. Outcomes of an experimental research of different adhesive systems are in-process resulted, values of toughness of adhesive connection are appreciated on values of a ultimate stress which arose at alteration of a sample of a composite material concerning a surface of a dentine of the tooth fixed in the plastic unit of a testing chamber. Findings of investigation confirm, that toughness of adhesive communication is determined by phylum of adhesive system essentially influential on anchoring strength of a composite material from dentinomas of a tooth. Check of certainty of received outcomes is conducted.
Key words: адгезивная система, композитный материал, адгезия, adhesive system, a composite material, the adhesion
CAROTID STENOSIS: DIAGNOSIS AND MANAGEMENT TACTICS
Kostenko O.V.
UDC: 616.12-009.72
Abstract: Analysis of the main risk factors for carotid stenosis, modern invasive and noninvasive diagnostic techniques, and surgical methods of patients with carotid stenosis are discussed in this article. Recommendations on lifestyle changes, choice of the method of diagnosis and surgical tactics depending on the severity of neurological symptoms, the degree of carotid stenosis, the operational risk and rates of complications are represented
Key words: атеросклероз, стенозы сонных артерий, ультразвуковая диагностика заболеваний сосудов, каротидная эндартерэктомия, каротидная ангиопластика и стентирование, atherosclerosis, carotid stenosis, ultrasound diagnostics vascular disease, carotid endarterectomy, carotid angioplasty and stenting
SOME ASPECTS OF EPILEPSY IN CHILDREN
Kasaminskaya E.S., Maslova N.N.
UDC: 616.853-009.24
Abstract: Up to 75% of epilepsies start at childhood and adolescence. Epilepsy of childhood, due to processes of evolution of structures and functions of nervous system, has a number of peculiarities. Children have forms and combinations of seizures never met in adults. On one hand there are benign age-dependent syndromes, which have good response to treatment or passing by without treatment, without significant impact and newer resumed in adults. On the other hand there are malignant syndromes, including epileptic encephalopathies, which influence absolutely harmful on child’s development with long lasting consequences even after disappearance of seizures. Not only the disease itself but also anticonvulsant drugs may influence child’s maturation. The main effects affect the formation of higher cognitive functions and personality. In some cases of encephalopathies pathological epileptic brain activity can influence on cognitive development even without visible seizures. At the same time nervous systems growth influences the course of epilepsy, changing as well as types of seizures, as forms of epilepsy.
Key words: эпилепсия, дети, доброкачественные эпилепсии, эпилептические энцефалопатии, epilepsy, children, benign epilepsies, epileptic encephalopathy
CASE OF RARE PHENOTYPE OF HEREDITARY SPASTIC PARAPLEGIA
Mayorova N.G., Pavlov V.A.
UDC: 618.8-009.614-031.58
Abstract: The article contains results of a clinical history, genealogical, neurological, clinical and instrumental examination of a patient with hereditary spastic paraplegia. Obtained data confirm the complexity of diagnostics due to clinical polymorphism. To solve diagnostic problems of hereditary spastic paraplegia combination of clinical and instrumental studies and DNA research are used.
Key words: наследственная спастическая параплегия, нейропатия, нарушение когнитивных функций, нарушение функции мочеиспускания, ДНК исследование, hereditary spastic paraplegia, neuropathy, cognitive impairment, impaired bladder function, DNA research
ETHICAL-DEONTOLOGICAL EDUCATION - AN IMPORTANT COMPONENT OF TRAINING FUTURE DOCTOR
Nikitin G.A., Yankovaya T.N., Afanasenkova T.E.
UDC: 614.23:371
Abstract: The modern pedagogics of the supreme medical education is impossible without use of active methods of the teaching, allowing to raise not only motivation and quality of vocational training at students, but also a role of the person of the teacher in preparation of the future experts. To the higher school the active methods of training creating conditions for successful training and education of positive steady moral qualities of students - physicians are required. Clinical analysis of the patient by a technique of "small groups", allows to expand opportunities of pedagogical dialogue, to develop personal and subject motivation and to generate at the student-physician ethics-deontology aspects: mercy, compassion, kindly, advantage, validity, honor, etc. Besides at students skills of interpersonal interaction are fixed, and the humanistic position is formed. At direct dialogue with the patient to the student it is necessary not only to come into contact, but also to manage to gain, cause trust and to prove the expert. In a result such personal qualities of students as compassion, sympathy, desire to render the qualified help are shown. The active method of training, clinical analysis of the patient by a technique of " small groups », not only forces the future doctor to state the positions and sights with their argument, the account of probable mistakes and omissions, but also renders strong emotional impression, is a good background for fastening medical ethics-deontology principles that becomes the base in formation of the person of the future doctor.
Key words: методика «малых групп», воспитательная работа, этико-деонтологическое воспитание, method of "small groups", mentoring, ethical-deontological education