ACTION OF SELENIUM-CONTAINING METAL-COMPLEX SUBSTANCE ΠQ1983 ON EXTERNAL RESPIRATION IN EXPERIMENTAL RATS IN ACUTE HYPOXIA
Sosin D.V., Evseyev A.V., Pravdivtsev V.A., Evseyeva M.A.
UDC: 615.015+616-001.8
Abstract: Changes of external respiration parameters have been studied in experimental rats after oral introduction of new selenium-containing metal-complex substance πQ1983 in dose 100 mg/kg before and under action of acute hypercapnic hypoxia (AH+Hc). A substance for comparison was metabolic antihypoxant amthizole administered in similar way and dosage. The substances were introduced 90 min before (incubation period) placement of animals into hypoxic chambers with 1.0 L free volume. During each experiment as well as during AH+Hc a respiration curve called pneumobarogramm (PBG) was recorded continually. It has been established that the substance πQ1983 decreases parameters of lungs ventilation in the rats. According to PBG dynamics, rats protected by the substance demonstrated a high resistance level to the aroused acute hypoxia with hypercapnia, that expressed by weakening of early reactions from respiratory system under hypercapnia action, twice longer life span of animals in hypoxic experiment, and by rising of possibility to withstand low oxygen concentration. It has been proved that the substanceπQ1983 significantly surpass a substance for comparison amthizole in both antihypoxic activity and influence on external respiration parameters.
Key words: крыса, острая гипоксия, гиперкапния, антигипоксанты, внешнее дыхание, пневмобарограмма, rat, acute hypoxia, hypercapnia, antihypoxants, external respiration, pneumobarogramm
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ARF TUMOR SUPPRESSOR ACTIVATES SELECTIVE DEGRADATION OF MITOCHONDRIA – MITOPHAGY
Budina A.P., Soloviev A.S.
UDC: 616-006.04
Abstract: Increased rate of cancer cases contributes to the necessity to study molecular mechanisms of malignant transformation as well as molecular basis of tumor suppression by tumor suppressor genes. In this paper the role of ARF tumor suppressor in activating selective degradation of mitochondria (mitophagy) is discussed. With a osteosarcoma cell line, it was demonstrated that ARF overexpression leads to mitochondrial membrane depolarization and autophagy activation, in which damaged mitochondria are selectively delivered to autophagosomes for degradation by the process called mitophagy.
Key words: аутофагия, митохондрии, митофагия, опухолевый супрессор, ARF, autophagy, mitochondria, mitophagy, tumor suppressor, ARF
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EFFECT OF IODINE-CONTAINING THYROID HORMONES ON THE SYSTEM OF PROTEOLYSIS IN STRESS
Gorodetskaya I.V., Gusakova E.A.
UDC: [616.441:612.018:577.152.34]:612.017.2
Abstract: Experimental hypothyroidism (25 mg/kg merkazolil 20 days) becomes more pronounced, than in euthyroid rats, stimulation of the trypsin-like activity (TLA) in the liver, and particularly in the blood at the alarm stage of stress reaction, due to decrease of the activity of α -antitrypsin (α -AT) and α -macroglobulin (α -MG); at the stage of resistance it prevents the normalization of their activity; at the stage of exhaustion it promotes the most significant activation of proteolysis due to profound inhibition of the α -АT and α -MG activity. Administration of L-thyroxine (1.5-3.0 µg/kg 28 days) limits the increase of TLA at the alarm- and exhaustion stages, in the stage of resistance prevents it, eliminating the depression of antiproteinase activity.
Key words: йодсодержащие тиреоидные гормоны, стресс, трипсиноподобная активность, α -антитрипсин, α -макроглобулин, iodine-containing thyroid hormones, stress, trypsin-like activity, α -antitrypsin, α -macroglobulin
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EFFECT OF IODINE-CONTAINING THYROID HORMONES ON PRO/ANTIOXIDANT SYSTEM OF THE MYOCARDIUM IN STRESS
Evdokimova O.V., Gorodetskaya I.V.
UDC: 612.43:755.115
Abstract: Experimental hypothyroidism (intragastric administration of merkazalil at a dose of 25 mg/kg during 20 days) stimulates, whereas administration of small doses of L-thyroxine (intragastrically 1.5-3.0 µkg/kg during 28 days) limits intensification of lipid peroxidation in the myocardium during influence of stressors of different nature (physical, chemical and emotional) due to their effect on enzymatic activity (superoxide dismutase and catalase) and non-enzymatic (reduced glutathione, vitamins A, E and C) components of the antioxidant system.
Key words: йодсодержащие тиреоидные гормоны, стресс, антиоксидантная система, iodine-containing thyroid hormones, stress, antioxidant system
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POSSIBILITY OF RESUSCITATION SYSTEM AUTOРULSE (MODEL 100) IN PATIENTS WITH ABDOMINAL SEPSIS
Petrov V.S., Struk Yu.V., Nikolaev S.V., Petrova M.M.
UDC: 616.12-089.82:616.12-008.315-08+616-036.882-08:614.211
Abstract: In article cardiopulmonary resuscitation activities are discussed. Beneficial application of resuscitation system AutoPulse (model 100) has been studied during cardiopulmonary resuscitation. Use of resuscitation system AutoPulse allows providing high-quality, safe and effective chest compressions.
Key words: абдоминальный сепсис, внезапная остановка сердца, сердечно-легочная реанимация, непрямой массаж сердца, реанимационная система AutoPulse (модель 100), abdominal sepsis sudden cardiac arrest, cardiopulmonary resuscitation, chest compressions, resuscitation system AutoPulse (model 100)
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ANTIBACTERIAL AND HEALING EFFECT OF OZONE AND INTERACTIVE DRESSINGS IN SURGICAL TREATMENT OF INGROWN NAIL WITH APPLICATION OF LASER TEHNOLOGIES
Lelyanov A.D., Listratenkov K.V.
UDC: 616.596-007.44+612.014.464
Abstract: Ozone therapy and interactive dressings have been applied in 31 patients with ingrown nail after excision of the nail plate with laser in the treatment of postoperative wounds. Comparative analysis of the therapeutic action of the proposed technology and traditional method of treatment (32 patients) with the use of a 5% solution of potassium permanganate has been performed.
Key words: вросший ноготь, лазерохирургия, инфекция, озон, интерактивные повязки, инфекция, бактериология, ingrown nails, infection, ozone, interactive dressings, infection, bacteriology
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DELAYED PATHOMORPHOLOGICAL CHANGES IN TESTES OF EXPERIMENTAL RATS FOLLOWING SINGLE Γ-IRRADIATION
Al Meselmany M.A , Evseyev A.V., Shabanov P.D.
UDC: [576,311,347:612.617,6:614,876] 0,29,9
Abstract: Morphology of spermatocytes has been studied in the rat testes in different periods (days 3, 10, 90) following a single external γ-irradiation (doses 0.5 and 1.0 Gy). Investigations revealed elements of destruction in tubule apparatus of the testis (in 3-10 days after irradiation) and the signs of the following recovery of their structure (Day 90). It can be concluded that the signs of structure and function recovery of the rat testes were registered only in 3 months after a single external γ-irradiation. The signs of testis stromal oedema disappeared, and radiation damaged spermatogenic epithelium partially recovered.
Key words: семенники, γ-облучение, семенные канальцы, сперматогенный эпителий, крысы, testes, γ-radiation, seminal ducts, spermatogenic epithelium, rats
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PHARMACODYNAMICS AND CLINICAL APPLICATIONS OF PREPARATIONS BASED ON HYDROXYPYRIDINE
Pozhilova E.V., Novikov V.E., Novikova A.V.
UDC: 615. 015: 616-001.8
Abstract: This review presents the data on experimental and clinical studies of medicinal substances which are hydroxypyridine derivatives. The paper contains a detailed description of their antioxidant and antihypoxant properties. Particular attention is paid to pharmacodynamics and clinical application of ethyl methyl hydroxypyridine succinate (mexidol), ethyl methyl hydroxypyridine malate (etoxidol) and methyl ethyl pyridinol (emoxipine).
Key words: производные 3-оксипиридина, метилэтилпиридинол (эмоксипин), этилметилгидроксипиридина сукцинат (мексидол), этилметилгидроксипиридина малат (этоксидол), derivatives of 3-oxypyridine, methyl ethyl pyridinol (emoxipine), ethyl methyl hydroxypyridine succinate (mexidol), ethyl methyl hydroxypyridine malate (etoxidol)
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PATHOLOGY OF CARDIOCEREBRAL INTERACTIONS AND THEIR MANIFESTATION IN THE PSYCHOEMOTIONAL SPHERE
Tryasunova M.A., Maslova N.N., Ulasen T.V.
UDC: 616.831:616.12-06
Abstract: The article presents a review on the studies performed over the past 25 years. It is devoted to characteristics and mechanisms of cardiocerebral interactions, as well as specific psychoemotional manifestations in acute cardiovascular or cerebrovascular events.
Key words: инсульт, острый инфаркт миокарда, острый коронарный синдром, депрессия, тревога, маркеры воспаления, нейроиммуноэндокринная система, кардиоцеребральный синдром, stroke, acute myocardial infarction, acute coronary syndrome, depression, anxiety, inflammatory markers, neuro-immune-endocrine system, cardiocerebral syndrome
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A RARE CASE OF CONGENITAL BRAIN TUMOR (ASTROCYTOMA) IN A NEWBORN
Ibatulin A.G., Moskovaya L.P., Alimova I.L., Moiseenkova S.D.
UDC: 616.831-006.48-053.31
Abstract: The article presents a clinical case of congenital brain tumor in a newborn. Manifestation of the disease was not specific and led to the misdiagnosis of the septic process. This clinical case demonstrates difficulties in existing diagnostic opportunities and focuses on the necessity to include this pathology in the differential diagnosis algorithm if the neurological signs in newborns are noted.
Key words: новорожденный, врожденная опухоль, астроцитома, newborn, congenital tumor, astrocytoma
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EXPERIENCE IN COPAXONE ADMINISTRATION IN PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS (ACCORDING TO AN OBSERVION PROGRAM DISCLER-1)
Pysina A.M., Maslova N.N., Snytkina N.N.
UDC: 616.832-004.2
Abstract: The article presents the results of Copaxone administation in patients with relapsing-remitting multiple scleroses obtained at an interim analysis of data during the observing program DISCLER-1. The data on efficacy and safety of the medicine are given.
Key words: рассеянный склероз, копаксон, DISCLER-1, multiple sclerosis, copaxone, DISCLER-1
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NOT HOPELESS PROBLEMS OF A DIDACTIC PROCESS AT A CLINICAL DEPARTMENT
Maslova N.N., Pavlov V.A., Kislyakova E.A., Yurieva N.V., Tryasunova M.A., Sergeev V.V., Maiorova N.G., Khamtsova E.I., Pysina A.M., Snytkina N.N.
UDC: 616.8 (07.07)
Abstract: The main spheres of activity at clinical teaching department are represented by academic and practical medical advisory work. In connection with formation and evolution of methodological work at universities, this process involves all the teachers and post-graduate students. Regular stress in teaching jobs affects the quality of student’s training. Accordingly this question could be solved by delegating the duties to a separate employee in every academic department since it allows the staff to be more efficiently involved into principle educational and practical activities.
Key words: методическая работа, обучение студентов, качество образования, methodological work, study of students, quality of education
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HISTORICAL BACKGROUND OF DISCOVERY OF INSULIN
Costaykov S.E., Demyanenko A.N.
UDC: 615. 252. 349
Abstract: The article describes the main stages in the development of Diabetology. It was made an attempt to consider the pathology of carbohydrate metabolism in the historical aspect. Medical studies resulted in the discovery of insulin are described in the paper.
Key words: сахарный диабет, инсулин, эндокринология, diabetes, insulin, endocrinology
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